Police lobbed a teargas canister at a crowd that was listening to him before they briefly pursued and arrested him at about midday.
Omondi had gathered a crowd along Kenyatta Avenue outside Bank of India which he was addressing when anti-riot police arrived.
He had climbed on a makeshift stand and had a huge rope around his neck complaining about the high cost of living. This attracted a crowd.
Police arrived and lobed a tear gas canister as others chased him.
He was arrested and taken to Central police station ahead of planned arraignment.
It is the latest time for Omondi to be arrested in drama.
He was last week detained as he pushed a handcart full of curriculum vitae to the State House.
He had March 1 arrested while distributing maize flour to his supporters at City Stadium in Nairobi.
The comedian-turned-activist had invited his fans to come for a packet of maize flour ahead of his planned demonstrations at State House.
Azimio La Umoja leaders called off planned protests on Monday after a truce with president William Ruto.
